Acute Pain is one of the leading disease states facing today’s society. In fact, 1 out of every 4 Americans experience pain; which ranks it the #1 most common ailment over hypertension, cancer and diabetes combined. Acute Pain comes on quickly and can be mild, moderate or severe but lasts relatively shorter periods of time, such as a few weeks, or until the injury is healed as compared to Chronic Pain which can last for months, years and in some cases a lifetime. Acute Pain can result from muscle strains, cramps, headaches, dental work, broken bones, child birth and surgeries in both the outpatient or hospital settings. Physicians tend to treat Acute Pain with opioid analgesics because they are effective for nociceptive pain or when a stimulus causes tissue damage to muscles, bones or other organs. Combination products that contain hydrocodone and acetaminophen have become the gold standard when treating Acute Pain because of their safety and effectiveness but these products are also associated with burdensome or unwanted opioid side effects such as nausea and vomiting. Opioid Induced Nausea and Vomiting (OINV) occurs in roughly 40-60% of the patients taking hydrocodone products for their pain management. Although not life threatening, and if left untreated, they can cause the patient to have very poor pain control thus leading to decreased ability to function and increased healthcare cost because of re-visits to doctors or hospitals. As with all medications, their effectiveness must be counterweighed by their possible side effects.
Because of the very well documented unmet need for a pain product that has a lower side effect profile, Charleston Laboratories, Inc is dedicated to developing novel opioid analgesics without Opioid Induced Nausea and Vomiting (OINV). Toward this goal, Charleston’s first drug in its pipeline of safe and effective strong analgesics without nausea and vomiting is CL-108. This acute analgesic was specifically designed to provide both pain relief and the reduction of nausea and vomiting for patients prescribed a strong analgesic for short-term use.